Leukocyte integrins: Role in leukocyte recruitment and as therapeutic targets in inflammatory disease
نویسندگان
چکیده
منابع مشابه
Leukocyte Beta2-Integrins; Genes and Disease
Integrins are heterodimeric transmembrane receptors that mediate cell-cell and cell-extracellular matrix interactions. Beta2-integrins are expressed exclusively in leukocytes and mediate many important functions in the immune system. Beta2-integrin genes are important in the pathologies of several diseases and genetic syndromes. These include Leukocyte Adhesion Deficiency (LAD) and Systemic Lup...
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Emigration of leukocytes from the circulation into tissue by transendothelial migration, is mediated subsequently by adhesion molecules such as selectins, chemokines and integrins. This multistep paradigm, with multiple molecular choices at each step, provides a diversity in signals. The influx of neutrophils, monocytes and lymphocytes into inflamed tissue is important in the pathogenesis of ch...
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ژورنال
عنوان ژورنال: Pharmacology & Therapeutics
سال: 2015
ISSN: 0163-7258
DOI: 10.1016/j.pharmthera.2014.11.008